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India, Africa and America) with pigmented populations and a history of improved social status with lighter complexion

10.1101/gad.343129.120 7 BourgeoisB.SpreitzerE.Platero-RochartD.PaarM.ZhouQ.UsluerS.et al (2025)

However, some mild side effects may occur, especially during the adjustment period or at higher doses: Headaches Temporary injection site irritation Lightheadedness Water retention (in rare cases) Mild tingling or numbness (from elevated IGF-1) Ipamorelin induced growth hormone release without elevating cortisol or ACTH levels, suggesting minimal off-target effects. Raun et al., European Journal of Endocrinology Compared to Other Peptides Unlike GHRP6 , which often causes intense hunger and spikes in prolactin , or GHRP2 , which can increase cortisol , Ipamorelin is more targeted and stable

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